Bendamustine hydrochloride

• CAS: 3543-75-7
• Catalog Number: ACM3543757
• Category: Main Products
• Molecular Weight: 394.72
• Molecular Formula: C₁₆H₂₂Cl₃N₃O₂
• Synonyms: bendamustine hydrochloride;BENDAMUSTIN HYDROCHLORIDE;CYTOSTASAN;1-methyl-5-bis(2-chloroethyl)amino-2-benzimidazolinebutryric acid hydrochloride;4-[5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]butanoic acid hydrochloride;1-methyl-5-bis(2-chloroethyl)amino-2-benzimidazolinebutryricacihydrochlor;gamma(1-methyl-5-bis(beta-chloraethyl)aminobenzimidazoyl-2)buttersaeurehydro;BENDAMUSTINE HCL
• IUPAC Name: 4-[5-[bis(2-chloroethyl)amino]-1-methylbenzimidazol-2-yl]butanoicacid;hydrochloride
• Canonical SMILES: CN1C2=C(C=C(C=C2)N(CCCl)CCCl)N=C1CCCC(=O)O.Cl
• InChI Key: ZHSKUOZOLHMKEA-UHFFFAOYSA-N
• Melting Point: 149-151°C
• Appearance: powder
• Exact Mass: 393.07800
• Hazard Statements: T,Xn
• Safety Description: 36-37
• Supplemental Hazard Statements: H301-H341-H351-H361-H371
• Symbol: GHS06,GHS08

Synthetic Use

Upstream Synthesis Route 1

• 3543-74-6

• 3543-75-7

Reference: [1] Patent: US2014/31560, 2014, A1, . Location in patent: Paragraph 0113; 0114; 0115; 0116; 0117; 0118

Upstream Synthesis Route 2

• 109882-25-9

• 3543-75-7

Reference: [1] Organic Process Research and Development, 2011, vol. 15, # 5, p. 1063 - 1072
[2] Patent: WO2010/42568, 2010, A1, . Location in patent: Page/Page column 20-21
[3] Patent: US2013/184471, 2013, A1, . Location in patent: Paragraph 0158; 0159

Upstream Synthesis Route 3

• 1313020-24-4

• 3543-75-7

Reference: [1] Patent: WO2012/59935, 2012, A1, . Location in patent: Page/Page column 29-30

Downstream Synthesis Route 1

• 3543-75-7

• 109882-29-3

Reference: [1]Pharmazie,1987,vol. 42,p. 272 - 273

Downstream Synthesis Route 2

• 3543-75-7

• 109882-29-3
• 109882-26-0

Reference: [1]Pharmazie,1987,vol. 42,p. 272 - 273

* For details of the synthesis route, please refer to the original source to ensure accuracy.