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Flusulfamide for Use Against Plant Diseases of Highest Market Significance

Original Article:
Fungicides with Unknown Mode of Action

Stefan Hillebrand, et al.

Modern Crop Protection Compounds, 2019, 2, 911-932.

10.1002/9783527699261.ch23

This publication summarizes several fungicides whose mode of action is unknown, including fensulfonamides. Flusulfamide belongs to the benzenesulfonanilide chemical class and is a niche product active against a narrow range of fungal pathogens. Flusulfamide is a polar compound but has relatively low water solubility due to its high melting point. The main applications of flusulfamide include:

> Fluosulamide is used to control diseases caused by soil-borne pathogens from the order Plasmodiophorales (the only order of the plasmodiophorid group). In the past, this isolated group of obligate plant pathogens has been classified in either the protoctists kingdom or in the fungi kingdom.

> Flusulfamide is used mainly as a soil treatment for the control of the causal agent of clubroot disease of Brassicae (crucifer) crops, Plasmodiophora brassicae.

> Flusulfamide has been shown to reduce the incidence of powdery scab in potato (Spongospora subterranea var. subterranea). Since potato powdery scab is a vector of potato mop virus, it can also be shown to have indirect efficacy against this disease.

> Although flusulfamide has also shown antifungal activity against fungal plant pathogens (e.g. Botrytis cinerea, Pythium melonum etc.) at the cell assay level, it has never been registered for the treatment of these diseases.

The figure below presents the details of the use of flusulfamide for the control of plant diseases of highest market importance.

Chemicals Related in the Paper:

Catalog Number Product Name Structure CAS Number Price
ACM106917526 Flusulfamide Flusulfamide 106917-52-6 Price
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