Original Article:
Gellan gum in drug delivery applications
Milan Milivojevic, et al.
Natural polysaccharides in drug delivery and biomedical applications, 2019: 145-186.
10.1016/B978-0-12-817055-7.00006-6
Gellan gum is an anionic water-soluble exotetrasaccharide. The application of gellan gum in drug delivery has been widely concerned by more and more researchers, benefiting from its excellent properties such as its thermal stability, biocompatibility, non-toxicity, high transparency, mucoadhesion, acid stability and Excellent gelling ability. In this review, the author focuses on the application and research progress of gellan gum in the field of drug delivery.
1. Application of Gellan Gum in Peroral Drug Delivery
In some cases, conventional oral dosage forms may suffer from short gastric residence time, drug release at the wrong location, or rapid gastric release. It has been extensively studied for different oral delivery formulations, mainly for the delivery and/or retention of active pharmaceutical ingredients at specific sites in the gastrointestinal tract (GIT). The main reasons for this are not only its biodegradability and non-toxicity, but most importantly its stability over a wide pH range and its resistance to most GIT enzymes (i.e., pectinase, amylase, cellulase, papain, lipase, etc.) insensitivity. The dosage forms of gellan gum that have been developed include tablets, capsules, gels and multiparticulate drug delivery systems.
2. Application of gellan gum in other drug delivery routes
Other routes that gellan gum is used in drug delivery include nasal drug delivery, topical (dermal, cutaneous, subcutaneous, transdermal) drug delivery, ophthalmic drug delivery, etc. For example, in ophthalmic drug delivery, gellan gum has thickening and gelling properties, good tolerance, transparency, and very low toxicity, and is used in in situ gelling systems for drug delivery. In many cases, gellan gum has been used with other polymers as an ingredient in complex ocular formulations. Among these polymers, alginate, carrageenan, chitosan, and carboxymethylcellulose are the most commonly used ones.
Chemicals Related in the Paper:
| Catalog Number | Product Name | Structure | CAS Number | Price |
|---|---|---|---|---|
| ACM71010521 | gelrite gellan gum |  |
71010-52-1 | Price |
