4-Hydroxy-2,2,6,6-tetramethyl-piperidinooxy

• CAS: 2226-96-2
• Catalog Number: ACM2226962
• Category: Other Products
• Molecular Weight: 172.24
• Molecular Formula: C9H18NO2
• Description: 4-Hydroxy-TEMPO or TEMPOL, formally 4-hydroxy-2,2,6,6-tetramethylpiperidin-1-oxyl, is a heterocyclic compound. Like the related TEMPO, it is used as a catalyst and chemical oxidant by virtue of being a stable radical. Its major appeal over TEMPO is that is less expensive, being produced from triacetone amine, which is itself made via the condensation of acetone and ammonia. This makes it economically viable on an industrial scale.In biochemical research, it has been investigated as an agent for limiting reactive oxygen species. It catalyzes the disproportionation of superoxide, facilitates hydrogen peroxide metabolism, and inhibits Fenton chemistry.
• Synonyms: 4-Hydroxy-2,2,6,6-te;4-Hydroxy-2,2,6,6-tetramethylpiperidine 1-oxyl,TEMPOL;HYDROXY-TEMPO;NR-I;4-Hydroxy-TEMPO Free Radical
• Melting Point: 69-73ºC
• Flash Point: 146°(295°F)
• Density: 1.187 g/cm³
• Appearance: Orange crystals
• EC Number: 218-760-9
• Hazard Codes: Xn
• Hazard Statements: Xn,Xi
• HS Code: 29333999
• LogP: 1.28370
• MDL Number: MFCD00006478
• PSA: 23.47
• Safety Description: 26-36-37/39-36/37/39-27
• Stability: Stable. Incompatible with strong oxidizing agents.
• Storage Conditions: 2-8ºC
• Supplemental Hazard Statements: H302-H315-H319-H335-H318
• Symbol: GHS05,GHS07
• WGK Germany: 1

Custom Q&A

What is the molecular formula of 4-hydroxy-TEMPO?

The molecular formula of 4-hydroxy-TEMPO is C9H18NO2.

What is the molecular weight of 4-hydroxy-TEMPO?

The molecular weight of 4-hydroxy-TEMPO is 172.24 g/mol.

What are some synonyms of 4-hydroxy-TEMPO?

Some synonyms of 4-hydroxy-TEMPO include 4-Oxypiperidol and 4-Hydroxy-2,2,6,6-tetramethylpiperidine-1-oxyl.

What is the role of 4-hydroxy-TEMPO?

4-hydroxy-TEMPO has a role as a radical scavenger, catalyst, nephroprotective agent, anti-inflammatory agent, neuroprotective agent, hepatoprotective agent, antineoplastic agent, and apoptosis inducer.

What is the InChI key of 4-hydroxy-TEMPO?

The InChI key of 4-hydroxy-TEMPO is UZFMOKQJFYMBGY-UHFFFAOYSA-N.

What is the Canonical SMILES of 4-hydroxy-TEMPO?

The Canonical SMILES of 4-hydroxy-TEMPO is CC1(CC(CC(N1[O])(C)C)O)C.

Which trials have used Tempol for the treatment of a specific condition?

Tempol has been used in trials studying the treatment of Anal Cancer.

What is the CAS number for 4-hydroxy-TEMPO?

The CAS number for 4-hydroxy-TEMPO is 2226-96-2.

What is the XLogP3-AA property value of 4-hydroxy-TEMPO?

The XLogP3-AA property value of 4-hydroxy-TEMPO is 0.9.

What is the hydrogen bond donor count of 4-hydroxy-TEMPO?

The hydrogen bond donor count of 4-hydroxy-TEMPO is 1.

Synthetic Use

Downstream Synthesis Route 1

• 7758-89-6
• 2226-96-2
• 309752-65-6

• 78119-82-1

Reference: [1] Patent: EP1186588, 2002, A1,

Downstream Synthesis Route 2

• 2226-96-2
• 79-41-4

• 760-93-0

Reference: [1] Patent: US2003/181763, 2003, A1,

Downstream Synthesis Route 3

• 2226-96-2
• 2351-36-2

• 112987-97-0
• 112987-99-2

Reference: [1]Journal of the American Chemical Society,1990,vol. 112,p. 7337 - 7346

Downstream Synthesis Route 4

• 45985-24-8
• 74-88-4

• 95407-69-5

Reference: [1]Journal of Organic Chemistry,1985,vol. 50,p. 1332 - 1334
[2]Organic Letters,2017,vol. 19,p. 1690 - 1693
[3]Journal of the American Chemical Society,1984,vol. 106,p. 3877 - 3878
[4]Journal of general chemistry of the USSR,1986,vol. 56,p. 753 - 758
Zhurnal Obshchei Khimii,1986,vol. 56,p. 855 - 860

Downstream Synthesis Route 5

• 110-52-1
• 2226-96-2

• 184946-34-7

Reference: [1]Current Patent Assignee: NORTH DAKOTA UNIVERSITY SYSTEM - US2007/66572, 2007, A1
Location in patent: Page/Page column 4

* For details of the synthesis route, please refer to the original source to ensure accuracy.